The 75 years old human females ovulation trigger paradigm is changing

The physiology of the menstrual cycle is central to human reproduction. The holy grail of the menstrual cycle is an ovulation trigger that signals the ovary to release an egg. There are two reproductive hormones, estradiol and progesterone that are required for ovulation, yet, only one of them can be a trigger. The current consensus holds that this pivotal role belongs to estradiol. At the same time, the progesterone in many ways seemed like a better candidate and there was a handful of experimental evidences of its ability to trigger ovulation. But, since 1930^th progesterone became known as a hormone of pregnancy, which blocks ovulation so that menstruations stop while woman is carrying a baby. Moreover, the entire birth control pills industry is using progesterone derivatives – progestins – to block ovulation. Thus, reconciling progesterone ability to trigger ovulation with its well-established ability to block ovulation remained a mystery for almost a 75 years and textbooks were teaching that ovulation is triggered by estradiol. In a series of publications Dr. Dozortsev in collaboration with Dr. Dimond of Augusta University and Dr. Pellicier, of IVI, Italy, has proposed a well corroborated theory that resolves progesterone paradox and explains how progesterone may trigger ovulation during a narrow time-window at the end of the follicular phase of the menstrual cycle, while blocking it at any other times or when administered in the form of progestins in the birth control formulations. Furthermore, it opened the door to elucidating the mechanism of the polycistic ovarian syndrome (PCOS) one of the most common and yet misterios disorder in females. 

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